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Journal of Research in Nursing
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research-article

Apoptosis and haemorrhagic shock

William J Mach

School of Nursing, University of Kansas, Kansas City, Kansas, USA

Amanda R Knight

School of Nursing, University of Kansas, Kansas City, Kansas, USA

James A Orr

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA

Janet D Pierce

School of Nursing, University of Kansas, Kansas City, Kansas, USA

Abstract

This is a review paper that provides an overview of current information on programmed cell death in haemorrhagic shock, including the identification of different molecular receptor signals. A PubMed search for all dates was undertaken using the search terms apoptosis, trauma and haemorrhagic shock. Original research, sentinel and review papers from peer-reviewed journals were included for identification of key concepts. Haemorrhagic shock remains a primary cause of death in civilian and military trauma. Apoptosis is accelerated following haemorrhagic shock. Many methods are used to detect and quantify apoptosis. Fluid resuscitation regimens vary in their effect on the extent of apoptosis. Investigators are examining the effects of haemorrhagic shock and fluid resuscitation on apoptotic signalling pathways. Molecular information is becoming available and being applied to the care of patients experiencing haemorrhagic shock, making it essential for nurses and other health care providers to consider the mechanisms and consequences of apoptosis.

Key Words: apoptosis • haemorrhage • resuscitation • signal transduction

Journal of Research in Nursing, Vol. 14, No. 1, 77-88 (2009)
DOI: 10.1177/1744987108092297
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